The mechanism of action of the drug is still not clear. In the study of silibinin labeled 14C, the highest concentrations found in the liver and very minor amounts – in the kidneys, lungs, heart and other organs.It is metabolized in the liver by conjugation. The bile as metabolites detected glucuronides and sulfates. The half-life time is 6 hours. Write mainly in bile (approximately 80%) in the form of glucuronides and sulfates, and to a minor extent (about 5%) in urine.Toxic omnadren 250 cycle liver disease.Status after acute hepatitis.Chronic hepatitis non-viral etiology.Hepatic steatosis (alcoholic and non-alcoholic).In the treatment of cirrhosis of the liver.Prevention of hepatic lesions during prolonged medication, alcohol, and chronic intoxication (including professional).
Hypersensitivity to the active, or any of the excipients of the drug. Children under 12 years of age.
Use during pregnancy and breastfeeding
is not recommended to use the drug during pregnancy and breastfeeding.
Dosing and Administration
Drops taken orally before meals, drinking plenty of water.
The course of treatment lasts at least 3 months.
Adults and children over 12 years:
the treatment of serious liver disease starts with a daily dose of 420 mg (4 tablets 3 times a day).
In milder cases and as maintenance omnadren 250 cycle therapy – 1-2 tablets 3 times a day.
Oseltamivir take 2-3 pills a day.
The drug is well tolerated. Rarely observed the following side effects:
- on the part of the gastrointestinal tract: nausea, dyspepsia, diarrhea.
- on the part of the skin: in rare cases, possible allergic skin reactions – itching, rash, alopecia.
Other: rarely can observe the strengthening of existing vestibular disorders.
Side effects are transient and disappear after discontinuation of the drug.
No data on drug overdose.
If you accidentally receiving a high dose is necessary to induce vomiting, gastric lavage using activated carbon and carry out symptomatic treatment if necessary.
Interaction with other medicinal products
In a joint application of silymarin with oral contraceptives and drugs used in hormone replacement therapy, may reduce the effects of the latter.
Silymarin may enhance the effects of drugs such as diazepam, alprazolam, ketoconazole, lovastatin, vinblastine because of its inhibitory effect on cytochrome P-450 system.
Be wary appoint patients with hormonal disorders (endometriosis, uterine fibroids, breast carcinoma, ovarian and uterine, prostate carcinoma) due to a possible manifestation of estrogen-like effect of silymarin.
The medicament as adjuvant contains wheat starch, which may constitute a risk of deterioration in patients with celiac disease (gluten enteropathy), and glycerol, which can omnadren 250 cycle cause headaches or irritable effect on the gastric mucosa with high doses.
Drops 35 mg.
There are 10 pills in blister PVC – film and aluminum foil.
On 8 blisters with instruction for use in a cardboard box.
In a dry and dark place at a temperature no higher than 25 ° C. Keep out of the reach of children!
Do not use beyond the expiration date printed on the package.