omnadren cycle

Primary hypercholesterolaemia (heterozygous familial and non-family types IIa, IIb, and mixed), combined hypercholesterolemia and hypertriglyceridemia (with the ineffectiveness of diet therapy in patients with an increased risk of coronary atherosclerosis).
Ischemic heart disease: prevention of myocardial infarction, reduce the risk of unstable angina, treatment of atherosclerosis.
Hypersensitivity to the drug (to any omnadren cycle of the formulation components, including hereditary lactose intolerance), as well as other inhibitors of HMG-CoA reductase in the history of liver disease in the acute phase. The increased activity of “liver” transaminases (unknown etiology) more than 3 times, the general plight of the patient, pregnancy, lactation, age 18 years (safety and efficacy not established).

The caution
in liver disease (history), alcohol abuse, after organ transplantation, concomitant immunosuppressive therapy, chronic renal insufficiency (creatinine clearance less than 30 ml / min.), Urgent surgical procedures (including dental), while taking gemfibrozil and other fibrates, nicotinic acid (more than 1 g / day), because of the risk of myopathy.

Pregnancy and lactation
Due to the fact that inhibitors of HMG-CoA reductase inhibitors inhibit the synthesis of cholesterol and cholesterol and other products of its synthesis are essential in fetal development including synthesis of steroids and cell membranes, lovastatin can cause adverse effects on the fetus in the appointment his pregnant (women of reproductive age should be carefully observed for contraceptive measures). If in the course of treatment there is a pregnancy, the drug should be withdrawn and the woman warned of the possible danger to the fetus.
The data in the allocation of lovastatin in breast milk are absent (however obtained experimental data on the penetration of the drug into the breast milk of rats), so breast-feeding during treatment should be discontinued.

Dosing and Administration
Inside, during a meal, in hypercholesterolemia starting dose – 10-20 mg 1 time a day, in the evening, in atherosclerosis – 20-40 mg / day. If necessary, increase the dose every 4 weeks. The maximum daily dose – 80 mg in 1 or 2 divided doses (at breakfast and dinner).
In the case of reducing the total cholesterol concentration in the plasma to 140 mg / 100 mL (3.6 mmol / L) or low density lipoproteins to 75 mg / 100 ml (1.94 mmol / l), the dose should be reduced.
when concomitant administration with drugs that suppress the immune system, as well as in severe chronic renal insufficiency (creatinine clearance less than 30 ml / min) daily dose should not exceed 20 mg (recommended dose – 10 mg / day.).

Side effect From the digestive system: heartburn, nausea, diarrhea or constipation, bloating, abdominal pain, dry mouth, taste disturbance, loss of appetite, cholestatic jaundice, abnormal liver function, increased activity of “liver” transaminases, hepatitis, acute pancreatitis. On the part of the central nervous system: dizziness, omnadren cycle headache, weakness, convulsions, insomnia, paresthesia, mental disorders. On the part of the musculoskeletal system: myalgia, myositis, myopathy, rhabdomyolysis (in patients receiving concomitant ciclosporin, gemfibrozil or nicotinic acid ( more than 1 g / day)), arthralgia. From the side of hematopoiesis: hemolytic anemia, leukopenia, thrombocytopenia. From the senses: blurred vision, cataract, cataracts, optic atrophy. Laboratory findings: increased activity of “liver” transaminases, increased activity of creatine phosphokinase (CPK), alkaline phosphatase, bilirubin, eosinophilia, ESR acceleration, a positive test for antinuclear antibodies. Allergic reactions: urticaria, angioedema, toxic epidermal necrolysis (Lyell’s syndrome), pruritus, rash. Other: reduction of potency, acute renal failure (due to rhabdomyolysis), chest pain, palpitations.

Overdose
The company has no information about overdose symptoms.

Interaction with other medicinal products
Immunosuppressive agents, fibrates (gemfibrozil), nicotinic acid (greater than 1 g / day.), Cyclosporine, erythromycin, azole antifungals group (itraconazole, etc.) Increase the risk of rhabdomyolysis, myopathy, acute renal failure. Proximity effect anticoagulants and risk of bleeding. Need for regular monitoring of the prothrombin time.
Cholestyramine and colestipol reduce bioavailability (using lovastatin possible after 2-4 hours after taking these drugs, it is noted an additive effect).
Cyclosporin increases the plasma concentrations of lovastatin metabolites. The use of grapefruit juice in large amounts increases the concentration of drug in the blood plasma, so their simultaneous use is not recommended.

Cautions
Patients should be warned that in case of unexplained muscle pain, tenderness and muscle weakness (especially in conjunction with a fever), they should consult a doctor.
During treatment, patients must be on a standard diet with low cholesterol.
In the case of persistent increase in blood “liver” transaminases and / or CPK shows removal of the drug.
therapy should be interrupted for a long period of time or terminated at the general grave condition of the patient, due to any disease.
when long-term therapy shows biochemical monitoring of liver function. The activity of “liver” transaminases determined before treatment every 8 weeks during the first year of therapy, then – at least 1 time in half a year. Patients whose daily dose is 80 mg, a study should be performed one time every three months. When the activity of “liver” transaminases, the study should be repeated in the future and spend it more often. In the case of the growth of levels of hepatic transaminases, especially when exceeding 3 times the upper limit of normal, the drug should be discontinued.
In the case of missing the current drug dose must be taken as soon as possible. If you come during omnadren cycle the next dose, the dose does not increase.

Form release
tablets 20 mg and 40 mg.
Of 10 or 30 tablets in blisters of PVC film and aluminum foil or in blisters of aluminum foil. 3 blisters of 10 tablets or 1 blisters of 30 tablets together with instructions for use in paper cartons.

Storage:
In a dry, dark place at a temperature of 12 ° C to 15 ° C
Keep out of reach of children.

Shelf life
2 years. Do not use after the date printed on the package.

Conditions of supply of pharmacies
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