Liver dysfunction, lactose intolerance, lactose deficit basins and glucose-galactose malabsorption.Is contraindicated in women and must not be given to pregnant or lactating. Adult males (including the elderly): the interior of 150 mg once a day. mg should be taken for a long time, for at least 2 years. If signs of progression of the disease taking the drug should be discontinued.
Violations of the liver: with mild hepatic dysfunction dose adjustment is required. In patients with moderate and severe hepatic impairment increased accumulation of the drug can omnadren jelfa be observed .
Except where expressly stated otherwise the frequency of side effects is calculated according to research monotherapy Casodex ® 150 mg of prostate cancer early. Very commonly (≥10%): gynecomastia (may persist even after the cessation of therapy, particularly in the case of taking the drug for a long time), pain pectoral glands, skin rash, asthenia. -Frequently (≥1% and <10%), depression, anorexia, dizziness, drowsiness, “tides” heat, itching, abdominal pain, constipation, dyspepsia, flatulence, alopecia or restoration of hair growth / hirsutism, dry skin, hematuria, nausea, decreased libido, erectile dysfunction, chest pain, oedema, weight gain, increased transaminases, hepatotoxicity, jaundice, anemia, loss of appetite. -nechasto (≥0, 1% – <1%): hypersensitivity reactions, including angionevro- matic swelling and hives, interstitial lung disease (reported cases with fatal outcome) *. -rare (≥0,01 – <0,1%): hepatic failure (reported cases with fatal outcome) *. a transient increase in activity of “liver” transaminases, cholestasis and jaundice rarely rated as serious, were transient in nature, completely disappeared or decreased with continued therapy or after drug discontinuation. Very rarely during treatment with bicalutamide developed liver failure, but a causal relationship between the development of liver failure and treatment of drug omnadren jelfa reliably is not installed. * Based on post-marketing use of the drug.
Cases of overdose have not been described in humans. There is no specific antidote. Treatment is symptomatic. Dialysis is not effective, since bicalutamide is closely associated with proteins and excreted in the urine in unchanged form. Shown general supportive treatment and monitoring of vital body functions.
Interaction with other medicinal products and other forms of drug interaction. You may need to decrease the dose of these drugs, particularly in the case or the potentiation of side reactions. After the introduction or withdrawal of the drug recommended careful monitoring of cyclosporin plasma concentrations and the clinical condition of the patient.
Simultaneous use of the drug and drugs that inhibit micro somalnye liver enzymes, such as ketoconazole or cimetidine may lead to increased concentrations of bicalutamide plasma, and possibly an increase in the incidence of adverse effects.
Increases the coumarin anticoagulants, including warfarin.
Considering the possibility of slower excretion and accumulation of bicalutamide bicalutamide in patients with impaired hepatic function, it is advisable to periodically assess liver function. Most of the changes of liver function occur in the first six months of treatment with .
In the case of pronounced omnadren jelfa changes in liver function receiving the drug should be discontinued.
In patients with disease progression on higher pro- statspetsificheskogo concentration of antigen (PSA) should be considered to terminate treatment .
In appointing the drug in patients receiving anticoagulants coumarin, it is recommended to regularly monitor the prothrombin time.
Effects on ability to drive and use other mechanisms
When applying the drug Casodex ® may experience drowsiness or dizziness. In this connection should be careful when driving vehicles or other moving machinery.
tablets covered with a foil liner 150 mg. On 14 tablets in a blister of the Al / PVC. 2 blisters in a carton box with instructions for use.
at temperatures below 30 o C, out of reach of children.
Do not use beyond the expiration date printed on the package.